- Savings & Loan Associations, Sharpsville
- Savings Banks, Sharpsville
- Scrap & Waste Materials, Sharpsville
- Screen Printing, Sharpsville
- Seafood Restaurants, Sharpsville
- Secondary Schools, Sharpsville
- Secretarial & Court Reporting Services, Sharpsville
- Sewer & Drain Cleaning & Repair, Sharpsville - Drain Cleaner & Installation Services
- Sheet Metal Contractors, Sharpsville - Sheet Metal Fabrication
- Sheet Metal Fabricators & Ductwork Contractors, Sharpsville
- Shopping & Shopping Services, Sharpsville
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- Slag, Sharpsville
- Snacks & Desserts, Sharpsville
- Snow Removal Services, Sharpsville - Snow Plow Service
- Social Services & Welfare, Sharpsville
- Societies & Foundation Associations, Sharpsville
- Specialty Animal Services, Sharpsville
- Specialty Stores, Sharpsville
- Sporting Goods Stores, Sharpsville
- Steel Manufacturers, Sharpsville
- Stoves & Furnace Equipment, Sharpsville - Fittings & Repair Parts
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