- Salvage Yards, Junk Yards & Wrecker Service, Edinboro
- Sand Gravel & Aggregate, Edinboro
- Sandwich Shop Restaurants, Edinboro
- Satellite & Cable TV Equipment & Systems, Edinboro
- Satellite TV Service, Edinboro
- Screen Printing, Edinboro
- Secondary Schools, Edinboro
- Security Brokers & Dealers, Edinboro
- Shopping & Shopping Services, Edinboro
- Signs, Edinboro
- Snack Foods, Edinboro
- Snacks & Desserts, Edinboro
- Social Services & Welfare, Edinboro
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- Societies & Foundation Associations, Edinboro
- Special Dies Tools Jigs & Fixtures Manufacturers, Edinboro
- Specialty Animal Services, Edinboro
- Specialty Stores, Edinboro
- Sporting Goods Equipment Rental, Edinboro
- Sporting Goods Stores, Edinboro
- Sports & Recreational Services, Edinboro
- Staffing & Support Services, Edinboro
- State Government, Edinboro
- Steel Rule Dies, Edinboro
- Stereo, Audio & Video Equipment Dealers & Stores, Edinboro
- Stocks & Bond Brokers, Edinboro
- Substance Abuse Outpatient Clinics, Edinboro
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