- Safety & Security Systems & Consultants, Duncannon
- Sandwich Shop Restaurants, Duncannon
- Satellite & Cable TV Equipment & Systems, Duncannon
- Satellite TV Service, Duncannon
- Savings & Loans Institutions, Duncannon
- Savings Banks, Duncannon
- Scrap & Waste Materials, Duncannon
- Senior Citizens Service & Health Organizations, Duncannon
- Service Establishment Supplies & Equipment, Duncannon
- Sewage Treatment Plant Contractors, Duncannon
- Shoe Stores, Duncannon - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Duncannon
- Signs, Duncannon
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- Snacks & Desserts, Duncannon
- Social Services & Welfare, Duncannon
- Societies & Foundation Associations, Duncannon
- Speciality Food Stores, Duncannon
- Specialty Stores, Duncannon
- Specialty Vehicle Rental & Leasing, Duncannon
- Sporting Goods Stores, Duncannon
- Sports Bars & Lounges, Duncannon
- State Government, Duncannon
- Stone Setting Contractors, Duncannon
- Submarine Sandwich Restaurants, Duncannon
- Surveyor Services, Duncannon - Surveying Service
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