- Sandwich Shop Restaurants, Curwensville
- Savings & Loan Associations, Curwensville
- Savings Banks, Curwensville
- Sawmill & Planing Mills, Curwensville
- Sawmill Supplies & Equipment Repair, Curwensville
- Secondary Schools, Curwensville
- Sewing & Yarn Stores & Supplies, Curwensville
- Shopping & Shopping Services, Curwensville
- Smoked Meat Restaurants, Curwensville
- Snacks & Desserts, Curwensville
- Social Services & Welfare, Curwensville
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- Sod & Sodding Service, Curwensville
- Specialty Animal Services, Curwensville
- Specialty Goods Storage, Curwensville
- Specialty Stores, Curwensville
- Sporting Goods Stores, Curwensville
- Sportswear Manufacturers, Curwensville
- Sportswear Wholesale, Curwensville
- Steel Manufacturers, Curwensville
- Street Cleaning Equipment, Curwensville
- Submarine Sandwich Restaurants, Curwensville
- Surveyor Services, Curwensville - Surveying Service
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