- Salvage Yards, Junk Yards & Wrecker Service, Brookville
- Sandblasting, Brookville - General Contractors
- Sandwich Shop Restaurants, Brookville
- Satellite & Cable TV Equipment & Systems, Brookville
- Satellite Dish Antennas & Equipment Dealers, Brookville
- Scrap & Waste Materials, Brookville
- Sculptures Retail, Brookville
- Sealants Retail, Brookville
- Secondary Schools, Brookville
- Secretarial & Court Reporting Services, Brookville
- Security Alarm Systems - Home & Business, Brookville
- Security Brokers & Dealers, Brookville
- Security Control Systems & Monitoring, Brookville - Polygraph, Lie Detector, CCTV, Fire Sensor Equipment, Etc
- Security Services, Brookville
- Senior Citizens Housing, Brookville
- Septic Tank Installation & Repair, Brookville - Septic Systems
- Septic Tank Pumping & Cleaning, Brookville - Septic Systems
- Septic Tanks & Septic Systems Contractors, Brookville - Installation, Repair, Service, Cleaning & Pumping Septic Tanks
- Septic Tanks & Systems, Brookville - Wholesale, Dealers & Suppliers
- Sewer & Drain Cleaning & Repair, Brookville - Drain Cleaner & Installation Services
- Sewing & Yarn Stores & Supplies, Brookville
- Sharpening Service, Brookville
- Sheet Metal, Brookville
- Sheet Metal Work - Aluminum, Tin, Stainless Steel, etc, Brookville - Sheet Metal Products
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- Shoe Stores, Brookville - Mens, Womens & Kids Shoes
- Shopping & Shopping Services, Brookville
- Siding Contractors, Brookville - Vinyl Siding, Wood, Metal & Aluminum Siding Contractors - Installation & Repair
- Siding Materials, Brookville
- Signs, Brookville
- Snacks & Desserts, Brookville
- Snow Removal Equipment Repair & Service, Brookville
- Snow Removal Services, Brookville - Snow Plow Service
- Social Clubs & Organizations, Brookville
- Social Services & Welfare, Brookville
- Social Workers & Services, Brookville
- Societies & Foundation Associations, Brookville
- Special Interest Schools Or Instruction, Brookville
- Specialty Communication Companies & Services, Brookville
- Specialty Goods Storage, Brookville
- Specialty Stores, Brookville
- Sporting Goods Stores, Brookville
- Staffing & Support Services, Brookville
- State Government, Brookville
- Steel & Metal Goods, Brookville - Steel Distributors
- Steel Manufacturers, Brookville
- Stocks & Bond Brokers, Brookville
- Submarine Sandwich Restaurants, Brookville
- Surveyor Services, Brookville - Surveying Service
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